With the teaching experience and practice of civil engineering specialty in Guangzhou University over the past years, based on the concept of "mutual financing, construction and mutual win", the collaborative education mode with "one central target, two collaborative models and three education platforms" for civil engineering has been established. This paper describes the construction of collaborative education mode, practice of cooperative education base and some safeguard measures of collaborative education mode to provide reference for the development of school enterprise cooperative education in colleges and universities.