The graduate degree theses on safety and correlative specialty were searched by Wanfang data. The number of thesis, topic selection and etc. of all national universities were figured out. According to statistics, fire science is the most popular research area in safety engineering specialty and discipline-crossing character is very obvious for fire science. The teaching practices and reform measures on graduation design (thesis) of safety engineering specialty of our institute were introduced in this paper. The quality of graduation design (thesis) can be improved by launching in advance, cooperation between college and enterprise, combining with scientific research, combining with the students' science and technology innovation and topic selection reform.