Combined with the problems in teaching process and learning experience in Queensland University of Technology, the paper discussed the difference between flipped classroom and traditional classroom, analyzed the characteristics of flipped classroom and requirements and problems of application-oriented undergraduate teaching, and also explored the advantages and challenges of using flipped classroom in application-oriented undergraduate teaching process. In order to take full advantages of flipped classroom and improve teaching quality, it is necessary to establish a guarantee mechanism to improve teachers' comprehensive quality, supervise students' learning and guarantee teaching facilities.