For the purpose of training applied talents, Heilongjiang Science and Technology University increased university-enterprise cooperating on "4+1" application talents mode. On the basis of summing up the existing researches, this paper analyzes the problems of current university-enterprise cooperation mode from the angle of enterprise benefit, probes into how to apply the idea of cooperative innovation to establish interest drive mechanism in five aspects of teaching, scientific research, service, information and employment, and ensures the healthy development of the university-enterprise cooperation mode