Market mechanism has unique advantages in resource allocation, and the introduction of market mechanism in the construction of science popularization informatization is conducive to promoting the sustainable development of science popularization informatization construction. However, the market is not omnipotent. The profit-seeking nature of social capital may affect the public welfare nature of science popularization work, thus affecting the sustainable operation of science popularization informatization. By combing the basic situation of market mechanism participating in science popularization informatization, this paper analyzes the advantages of market mechanism participating in science popularization informatization, explores the problems that may arise after the participation of market mechanism, and puts forward suggestions for the sustainable development of science popularization informatization construction in view of relevant problems.