Based on the definition of innovation and entrepreneurship education by many scholars, proposed that innovation and entrepreneurship education need innovation, education, universality, integration, progressiveness and closure, emphasized that colleges and universities must recognize that the essence of innovation and entrepreneurship education is education, talents training and practice. With student-oriented, combining the needs of enterprises, from the top level design, talent training programs, teachers, learning conditions, and practice of the entire teaching link,implement double creation education. Based on this, it is further refined into teacher training, classroom reform, discipline competition, textbook research, results transformation, and on-campus practice, so as to integrate the "five closed-loop" training mode of innovation and entrepreneurship education based on cooperation between schools and enterprises.