Based on the concept of engineering education professional certification, this paper analyzes the characteristics and the existing problems of course design of building engineering of Tongji University, and the virtual-real combination teaching mode is put forward adapted to the course design, therefore it can make up for the inadequacy of real class, and help students get results quickly. The practice shows that the virtual class and the real class can complement each other, the teaching method is flexible and diverse, and it can improve the teaching quality effectively.