Curriculum system is the main part of student training program of a major, and is the key factor of major characteristics and major connotation. It is also the base of major construction and major reform. In this paper, taking the curriculum system of civil engineering of Xi'an University of Architecture and Technology as an example, which is well reformed and optimized to strengthen major characteristics and enrich major connotation, the reforming and optimization practice of the core curriculum group, the elective curriculum system, the foreign language curriculum system, the bilingual curriculum system, the all English curriculum system, the innovation-entrepreneurship education curriculum system, the general education curriculum, and the online curriculum group are introduced. The curriculum system reform and practice experience introduced in this paper have good reference value for the designing of civil engineering course system and major construction in other colleges and universities.