Urban underground space engineering is one of the special professions of professional catalogue. Due to the short opening time, the phenomenon of heavy theory and light practice directly affects the quality of talent training. On the basis of investigating the problems faced by new professional practice teaching for urban underground space, Guangdong University of Technology takes advantage of regional economic development to cultivate application-oriented innovative underground space engineers, integrates various teaching resources inside and outside the school, and implements teaching reform and innovation of cooperative education. A series of measures were adopted, including a four-year continuous practice teaching system, a multi-level practice teaching platform, a practice teaching mode combining engineering simulation and practice, diversified scientific and technological activities and innovative experiments. Innovation education is integrated into the whole process of talent cultivation, and comprehensively enhances the engineering practice ability and innovation ability of college students.