Local colleges and universities have been infiltrated by regional culture for a long time, it is the foundation of the characteristic development of local colleges. The paper explores the main problems existing in the process of characteristic running, analyzes the main influence of regional culture. It is based on ecological niche theory, researches local colleges how to be absorbed regional cultural elements in the process of cultivate distinctive talents, and improves the quality of education through inheriting regional culture. Local colleges should renew the concept of talent training, reconstruct the characteristic curriculum system, expand the way of characteristic education, build the characteristic education platform, implement the characteristic education mode, realize the characteristic talent training, improve the talent training quality.