Facing the development needs of emerging engineering education and construction industry, talent cultivation plan of civil engineering major of Intelligent Construction College built based on school-enterprise cooperation by Heilongjiang Institute of Technology is researched. Training objective is established to meet the demand of building industrialization and intellectualization, and the curriculum system adapting to the transformation and upgrading of civil engineering specialty in local universities is constructed including engineering general education platform, professional foundation platform of civil engineering, new technology and interdisciplinary module, engineering and social module, innovation and entrepreneurship module, and intelligent construction module. A "3+1" training mode based on multi-agent cooperation is adopted which introducing enterprises to participate in education. Taking the Intelligent Construction College as the carrier, practical research is carried out to cultivate application-oriented undergraduate talents who adapt to the development of industrialization, digitization, and intellectualization of construction and are needed by enterprises, and it works well.