China's urbanization process has accelerated, and the opportunities for regional development have made the teaching of regional planning courses in urban and rural planning face challenges. Especially at present, the sustainable development of regional planning and the innovative development of comprehensive land and space planning show an urgent need to rely on the advancement of basic research and its innovation results. This article briefly analyzes the significant promotion effect of relevant basic research development on regional planning from three levels of theory, technology and practice, and further proposes that, in the critical stage of China's new era development, on the one hand, regional planning must be proactive and relevant to basic research. The combination of innovation and major breakthroughs can effectively promote the transformation and upgrading of China's regional planning. On the other hand, regional planning must actively integrate with the territorial and spatial planning system, and develop new demands for regional planning and curriculum teaching in accordance with the development of territorial and spatial planning at different levels. From the perspective of basic research and innovation, it puts forward the concept and path of regional planning curriculum teaching practice innovation, so as to provide continuous deepening and innovative talent preparation and theoretical preparation for land and space planning, and to promote the long-term sustainable development of land and space planning practice.