China’s Education Modernization 2035 focuses on the explicit problems and weak parts in education, and points out that it is necessary to strengthen the connection and integration of education and industrial development, and enrich and innovate curriculum forms. Digital modeling and simulation are the key content in the training of information technology ability, and the cultivation quality is of great significance to the teaching reform in universities. At present, application-oriented universities can not well meet the needs of enterprises in the cultivation of digital modeling and simulation. This requires universities to carry out industry-oriented teaching reform in curriculum contents. Engineering fluid mechanics is a school-level excellent course in Zhongkai University of Agriculture and Engineering, which plays an important role in improving the quality of talent cultivation. The teaching team actively uses modern information technology by introducing a three-level teaching method with computational fluid dynamics (CFD) simulation. The curriculum reform lays a foundation for further improving the adaptability of courses to industry needs by leading students to operate various engineering applications from simple cases to complex cases.