In view of the current situation that the graduation design of civil engineering is mostly implemented by students of each major alone and lacks multi-disciplinary cooperation, a joint graduation design teaching mode based on CDIOF-BIM is proposed. This model takes CDIOF as the guiding ideology, relies on actual engineering projects, takes BIM technology as the platform, and formulates corresponding teaching processes and practice methods. Through the analysis of CDIOF-BIM teaching practice examples, the feasibility of this teaching mode is verified. From the effect of implementation, this model has been recognized by teachers and students, and students' abilities in engineering design, information acquisition, and collaborative innovation have been improved.