Under the background of new engineering construction, the multi-level connotative education reform and practice is conducted, represented by the course of air conditioning, which is the core course of energy and power engineering in Harbin University of Commerce. The main contents of the reform include multi-dimensional interdisciplinary integration of theoretical course system, innovation and exploration improvement of practice teaching system, the construction of teaching materials and the revision of the syllabus, and the reform of teaching skills and examination methods. Construction of curriculum-based accurate ideological and political education is carried out, focusing on enhancing students’ comprehensive quality. After three years of teaching reform and exploration, the course system of air conditioning has been innovated, and the cultivation quality of high-quality talents has been significantly promoted for energy and power engineering major.