The development of vocational education has entered an important stage of improving image and quality. The level of students’ professional quality education has become the main index of the connotation construction of vocational colleges. Under the school running mode of industry education integration, the prominent contradiction between the diversified needs of students’ quality education and the insufficient connotation construction of professional quality education, the poor connection between the professional quality needs of industry posts and the school teaching mode, the insufficient linkage education between schools and enterprises, and the lack of follow-up in the evaluation and appraisal of the effect of professional quality education affect the high-quality development of professional quality education in higher vocational colleges. Taking the analysis of three main influencing factors of culture, management and evaluation as the starting point, put forward the “three integration and two guidance” vocational quality education framework, and explore the path of vocational quality education in higher vocational colleges by creating a cultural education environment integrating industry and education, building a complete and effective education system, and reflecting the professional quality evaluation of individual growth, in order to adapt to the characteristics of open enrollment, classified enrollment and vocational education without classes.