With the deep integration of information technology and education and teaching in the context of Internet plus, online teaching based on information technology is changing to the new normal. In the face of the current new normal of educational reform, how to update teaching concepts, adjust teaching strategies, grasp the real learning situation, and improve teaching quality in exploration and practice has gradually become a new focus of teaching practice. The architectural design course, as the core course of the architecture major, has the characteristics of strong practicality and high comprehensiveness. The article takes the course of campus architectural design in the architectural design course as the empirical research object, based on the relevant theories of blended learning, combines the teaching characteristics of architectural design with the advantages of online and offline teaching, and relies on high-quality online teaching platforms, explore and practice online diversified mixed architectural design teaching from five aspects: course objectives, teaching tasks, teaching organization teaching content and teaching evaluation. The analysis of practice effect shows that the online course teaching under the concept of multiple mixing can effectively stimulate students’ learning interest, promote the knowledge construction of systematic architecture discipline and improve the ability of innovative design thinking. In addition, online teaching under the concept of diversified mixing can provide practical experience for the online teaching design of architectural design and other design disciplines in the Guangdong-Hong Kong-Macao Greater Bay Area, and also have a positive promoting effect on the construction of first-class undergraduate courses in architecture.