To explore the path of independent cultivation of engineering science and technology innovation talents， this paper selects four engineering colleges with different types and different characteristics based on subject evaluation and Times ranking results， and compares and analyzes their innovative talent cultivation models from three dimensions such as training objectives， training processes， and support systems. It finds that the independent cultivation of engineering science and technology innovation talents requires the establishment of a classified cultivation mechanism， and different universities should cultivate different types of innovative talents. Based on this， a training path with student-centered， school characteristics and classified training is proposed. At the same time， a pyramid of innovative talent types is proposed， and a matrix diagram of the innovation level of innovative talents mainly engaged in innovative activities is constructed. Based on China’s national conditions， five suggestions for independent cultivation of innovative talents in Chinese universities are proposed.