Deepening the construction of Beijing-Tianjin-Hebei university alliance and meeting the demands of multi-agent collaborative innovation of government, industry, university and research institute are of great significance for promoting the high-quality development of higher education in the Beijing-Tianjin-Hebei Urban Agglomeration and enhancing the ability of universities to serve regional economic and social development. The Beijing-Tianjin-Hebei university alliance presents a trend of diverse levels、multi-dimensional directions and clear concepts, however, there is a gap between the construction level、construction effect and practical needs, and there are many problems in operation and management. From the perspective of multi-agent collaborative innovation and based on the demands of the service objects of the university alliance, this paper constructs a Beijing-Tianjin-Hebei university alliance model with the integration of government, industry, university and research institute guided by the common goal, focuses on the internal structure and operation mechanism of the university alliance, and suggests that it be guaranteed from the aspects of top-level design, management mechanism, information platform and cultural integration.