The teaching content and curriculum system reform project of university-industry cooperation for collaborative education of the Ministry of Education aims to introduce the latest requirements of talent cultivation into the teaching process, promote universities to update the teaching content, improve the curriculum system, build shareable resources that meet the development needs of the industry and promote their application. In response to the requirements of national strategy, considering the common problems in the teaching of theoretical courses in civil engineering and the characteristics of the course of seismic design of building structure, the teaching mode of industry-university cooperation and collaborative education is constructed based on the hybrid teaching method, which discusses the adjustment and optimization of teaching contents, the introduction of typical structural analysis software, the design of course assignments, the selection of test projects, the assessment method and the establishment and utilization of teaching and research test platform.The main ideas and key implementation steps of the teaching mode are described in detail, and the gains and inspirations in terms of theoretical knowledge, engineering application, innovative ideas and professional quality are listed, thus verifying the good effect of the teaching mode of industry-university cooperation and collaborative education.