Intelligent construction is based on traditional civil engineering majors,and it is a new direction of engineering development meeting the needs of national construction. As a core course of traditional civil engineering, the course of concrete structure design is still an important teaching link of intelligent construction. In order to meet the new requirements of talent cultivation, combined with the analysis of core courses of intelligent construction in domestic universities, this paper explores the reform measures of existing concrete structure design course knowledge, constructs a knowledge system suitable for concrete structure design courses under the background of intelligent construction, clarifies the role of concrete structure design in intelligent construction, and related achievements can provide reference for the teaching of structure design in intelligent construction.