The teaching reform of the construction project management course is an inevitable trend facing the transformation of the industry. As a comprehensive course, construction project management has higher requirements for the structure of knowledge units and the relevance with engineering practice. In order to meet the knowledge update requirements in the context of intelligent construction, this study modularizes the theoretical knowledge units of the course and constructs a targeted modular case system, and a case teaching mode is designed based on the PBL concept. Students’ understanding of theoretical knowledge is deepened through interspersed teaching methods, and the matching degree between case teaching and theoretical knowledge is effectively improved.