Labor education and innovation and entrepreneurship education have isomorphic symbiosis in connotation, goals, contents, methods and other aspects. The new situation of coordinated development of labor education and innovation and entrepreneurship education has put forward new requirements for the training of talents in road, bridge and river crossing engineering majors in higher education institutions. Subgrade and pavement engineering is the core course of road, bridge and river crossing engineering majors, which bears the important task of curriculum education. It always focuses on students, establishes the trinity curriculum goals, takes moral cultivation as the fundamental goal, and builds an education model that closely combines labor education, innovation and entrepreneurship education and professional education. Through the creation of hybrid online learning space, deeply exploring the elements of labor education and ideological and political education, implementing group competition-based teaching, promoting learning through competitions and research, and adopting diversified evaluation methods, knowledge is put into practice, students’ labor innovation awareness and ability are enhanced, and the quality of talent training is improved, so as to promote the reform of the curriculum of integration of labor and innovation in Chinese universities.