With the advancement of the educational informatization concept, virtual simulation experimental teaching has become an inseparable part of experimental teaching. However, there are issues with the current experimental teaching mode. First, the organic integration between virtual simulation projects and traditional physical experimental teaching systems is insufficient. Second, the cross-campus sharing mechanism of high-quality virtual simulation experimental resources urgently needs to be improved. This article takes the National Experimental Teaching Demonstration Center for Civil Engineering (Southeast University) as an example to introduce the exploration of the center in the virtual-real integration, sharing and blending experimental teaching mode. By constructing a virtual-real integration experimental teaching system in the civil engineering field, developing high-level virtual simulation experimental teaching resources, exploring new forms of future experimental teaching, constructing a standardized matrix for professional experimental teaching, and building a virtual simulation sharing platform, etc., the center promotes the cultivation of civil engineering leading talents with both morality and talent, builds a teaching team that is compatible with teaching, research, and technology, and promotes the application of the virtual-real integration teaching system, providing valuable reference for similar universities to deepen experimental teaching reform.