How to make use of the opportunity period of "One Belt And One Road" initiative to break through the bottleneck of its own development and go international is the top priority of guangdong higher education. Based on SWOT analysis, this paper points out the internal advantages and disadvantages of the internationalization development of higher education in guangdong province under the background of "One Belt And One Road" initiative, and puts forward the following points on the basis of opportunities and challenges faced by the outside world. Second, increase the government scholarship, optimize the "One Belt And One Road" scholarship allocation rules; Third, enhance the strength of colleges and universities and carry out high-quality sino-foreign education cooperation; Fourth, combining the characteristics of colleges and universities, the development of differentiated talent attraction strategy; Fifth, make full use of the guangdong-hong kong-macao greater bay area to build an international higher education center; Sixth, jointly build the vocational education alliance and create the "One Belt And One Road" characteristic brand.