At present, a systematic and comprehensive online and offline hybrid teaching model has not yet been formed.In particular, the application of hybrid teaching concept to the teaching and research of civil engineering specialty course is still very deficient. Based on the analysis of the characteristics of civil engineering specialty course and the problems existing in teaching, a hybrid teaching mode of online and offline integration is proposed. This teaching mode is based on multimedia PPT, blackboard book, MIRC network platform and course learning website. It adopts teaching methods such as lecture, discussion, task-driven and self-learning, and pays attention to the comprehensive application of teaching methods and teaching methods, which can minimize the fatigue of students in the process of learning and fully stimulate students" interest and potential in learning. The application results in the teaching of “building structure design” in the core professional course of civil engineering show that the proposed hybrid teaching mode of online and offline has better learning effect and contributes to the cultivation of innovative practical talents.