In recent years, it pays high attention to the innovation, entrepreneurship and creation education in the colleges and universities in China, and continuously explores that how to promote the implementation of the innovation, entrepreneurship and creation education in a more effective way. It’s an important approach to realize the goal of the higher education under the background of new engineering course by combining the innovation, entrepreneurship and creation education with the professional education. Currently, it makes a great progress and accumulates a lot of experience in the innovation, entrepreneurship and creation education, but there are also many problems existing. We explained the connotation of the innovation, entrepreneurship and creation education and the professional education and the relationship between them, and emphatically analyzed the principle issues face by the innovation, entrepreneurship and creation education and the professional education in this paper. In addition, we put forward the specific countermeasures in order to implement the innovation, entrepreneurship and creation education in the undergraduate colleges and universities better and provide reference for improving the creative idea, entrepreneurial practice and creative spirit comprehensively.