The construction of the course “earthquake resistance and disaster prevention of engineering structure” is very important to cultivate the comprehensive talents with both ability and morality in the field of disaster prevention and mitigation. To fulfill the basic task of cultivating talents with moral integrity, enrich teaching materials, teaching methods, teaching language, improve the activity of classroom, and guarantee the teaching quality of the course, the pedagogical reform is carried out. Combined with the professional interpretation and discussion of typical engineering damage, the “infiltrative” ideological and political teaching mode of the course have been established. The bilingual interactive teaching practice of the course have been implement through adopting bilingual teaching and the thematic instruction by the international famous experts. The students’ understanding on the knowledge of earthquake resistance and disaster prevention of the engineering structure have been promoted by strengthening the practical teaching of the course. The teaching resources sharing platform of the course has been established to share the high-quality teaching resources in time. Meanwhile, the teaching strategy of the course in epidemic period is explored, and the strategy is verified by the teaching practice during COVID-19 (Corona Virus Disease 2019). The teaching strategy and practice can provide some reference for the course of “earthquake resistance and disaster prevention of engineering structures” in the period of major epidemic.