According to?the?practical?teaching?characteristics?of?civil?engineering graduation?design, the paper puts forward?some?countermeasures?on?how?to?carry?out online?guidance?effectively?under?the?COVID-19?epidemic to?ensure?the progress?and?quality. The civil?engineering graduation?project?is?a?special?comprehensive training?that?combines professional?theory?and engineering?practice with?many?tasks. This paper analyzes the difficulties of on-line guidance of civil engineering graduation design, such as difficulty in finding professional design manuals and specifications, poor intuitiveness in drawing guidance and theoretical derivation, poor individual learning atmosphere, and difficulty in supervision by teachers. The paper probes into the countermeasures from the aspects of constructing the electronic literature database, using the multi-dimensional network teaching platform, enhancing the interactive activities, refining the task objectives, strengthening the process management and control, and guaranteeing the design quality and progress.Combining with the concrete case, the paper introduces the implementation process and the teaching effect, and forms a set of effective on-line guidance mode, which gives prominence to the principal position of students and the leading role of teachers, from the angle of quantity and quality, it achieves the expected teaching goal and effect, which can be used for reference in the online instruction of the same kind of design courses.