Subsidizing precision research is a key topic discussed by universities in recent years. Based on the implementation strategy of "precision poverty alleviation" policy put forward by general secretary Xi Jinping, this paper makes a survey of the current precision funding work in Colleges and universities, analyzes the current situation and existing problems of the subsidy work combined with the actual situation in Colleges and universities, and discusses the mechanism of precise assistance for college students based on the big data platform. Mechanism, collaborative security mechanism, funding and education mechanism to ensure the accuracy of university funding.