As an important professional foundation course of Civil Engineering, the purpose of Mechanics of Material is to train students to master solid basic mechanics knowledge, and students have the practical ability to integrate basic mechanics knowledge with engineering problems. At the present stage, a new round of scientific and technological revolution and industrial transformation is flourishing. Higher requirements are put forward for high quality creative talents who master solid mechanics foundation. However, some problems are still common, such as unattractive course, lack of interest in learning, or lack of ability to analyze and solve problems. Therefore, it will get great significance to carry out the teaching reform and exploration of Mechanics of material. Under the background of curriculum system reform which is aiming at engineering education certification and concept of OBE, the knowledge module of Mechanics of material was regrouped, and practical problems and engineering cases were introduced into the teaching process. The new teaching mode is explored. A variety of teaching methods were used, and the students’ interest in learning had been increased. Students gradually become the main body of learning, and the purpose of cultivating innovative talents who have creative consciousness and practical ability can be achieved.