To meet the demand of the development of building industrialization, a series of reforms in the graduation design of building construction orientation for civil engineering specialty has been carried out in South China University of Technology, which includes the adjustment on the graduation design objectives, topics, design content, implementation means, schedule, results submitted, etc. In order to ensure the smooth implementation of the reform, some effective measures have been taken. For example, the implementation path of the reform has been formulated by using PDCA cycle, so that the graduation design practice can be continuously improved year by year. The design of prefabricated concrete structure, BIM-based deepening design of prefabricated components, collision analysis, construction process simulation, measurement and pricing were introduced, making the traditional state of taking the structural design of cast-in-place concrete frame as a single design content changed. Through multi-dimensional university-enterprise cooperation, online and offline guidance mode and excellent student teaching assistants, the problems of lack of teachers and software application in the field of prefabricated structure design have been solved. Facilitated from the combination of competition and teaching, the teaching quality was promoted, and students’ ability and the time consuming for various tasks were measured. Finally, some issues, such as the choice between the traditional manual calculation content and the computer calculation content, the setting of the design content of the cast-in-place components and prefabricated components, the balance on design difficulty and workload, were discussed. The design task and schedule are suggested to be arranged based on the measurement results, and for students with different ability levels, the required and optional content can be set to meet their development needs. After the reform, the overall workload and difficulty of the graduation design have increased, and the design content is more in line with the engineering practice. The students' software application skills have greatly improved, and their understanding in the detailed structure, production and construction process of prefabricated components has been deepened. The reform has achieved good effect, providing a good basis and reference for the development of intelligent construction specialty.