From the view of integrated education of innovative entrepreneurship and professional ability, the formation mechanism of virtual teaching research center in colleges and universities was analyzed. Based on these results, two models of team learning community and teacher"s dynamic growth was presented to support the development of virtual teaching reseach center in colleges and universities. Furthermore, the concept of virtual teaching research center was then provided for the intrgrated education of innovative entrepreneurship and professional ability. A virtual teaching research center was then constructed combined the cultivate of civil engineering professional ability and innovative entrepreneurship. The organizational frame and its function were also proposed in order to obtain a better practice effect. The training effect for the students and teachers were evaluated by the practice progress in recent years in the college of civil engineering of Henan University of Technology.