By analyzing the innovation capability and talent innovation index of universities across 30 regions, this study identified 25 key factors that influence university innovation capability on talent innovation index using bivariate correlation analysis. The 25 factors were then subjected to factor analysis, which yielded three common factors: R D resources, innovation platform construction, and innovation subjects. Multiple regression analysis was conducted using the stepwise regression method to explore the significant influence of these three factors on the talent innovation index. Results showed that R D resources of regional universities play a crucial role in shaping the innovation talent index and the quality of innovation talent cultivation. Based on these findings, the study proposes three recommendations: prioritize the optimization of R D resources in regional universities, enhance the innovation platform of universities, and continuously improve innovative thinking and ability. These recommendations offer theoretical guidance for improving the quality of scientific and innovative talent cultivation across various majors in universities.