Due to the complex nature of wood, the high operational risk of various mechanical equipments and the lack of pertinence of safety education, the woodworking machinery laboratory inuniversitiesoftenhavehighexperimentalsafetyrisks. With the rapid development of the digital economy, the research on intelligence automation and visualization of laboratory has been progressing, and virtual simulation and visual simulation have brought new opportunities to optimize safety risk management and control mode of woodworking machinery laboratories. This project explores the risk control measures of virtual andrealitycombination and the innovation of the safety education mode from three aspects which are “mechanical equipment, experimental environment and virtual project”, and further evaluates the application effectiveness. The practice shows that the laboratory safety risk management and control mode combining virtual and real can effectively improve students’ awareness of experimental risks, strengthen students’ psychological cognition of safety, and effectively promote the expansion of experimental safetyeducationand training methods, which has positive reference value for universities to improve the quality of experimental practice teaching and implement experimental safety technology management.