The undergraduate thesis (design), as the final and most important step in undergraduate education, serves not only as a crucial means to test students" mastery of fundamental theoretical knowledge, essential professional skills, and innovation spirit, but also as a key indicator for assessing the quality of undergraduate teaching and talent cultivation in higher education institutions. Yet, the traditional undergraduate thesis (design) mode suffers from a series of problems, such as topics lacking practical value, insufficient process supervision, and difficulties in translating outcomes into practical applications. In response, the Department of Disaster Mitigation for Structures, Collage of Civil Engineering, Tongji University, has proposed an undergraduate thesis (design) mode empowered by integration of Science-Industry-Education, using the application of large-scale instruments in the State Key Laboratory as a case study. It drives education reform in work through four key aspects: optimizing topic selection, innovating teaching methodologies, enhancing progress supervision, and implementing the translation of research outcomes. The successful application of this new mode in an undergraduate thesis demonstrates that this new mode not only fosters well-rounded talent development—enhancing students" comprehensive abilities in project management and engineering design, communication and teamwork, as well as professional knowledge and problem analysis—but also provides valuable references and experiences for the specialty construction of civil engineering. In response to problems identified during implementation of the new mode, the paper conducts in-depth reflection and proposes corresponding improvement measures.