The undergraduate education is of vital strategic importance, and the major acts as the basic unit and basic platform of talent training. The major of Urban Underground Space Engineering in Southeast University has a profound historical origin. Based on the practice and exploration on the first-class undergraduate course of Urban Underground Space Engineering in Southeast University, this paper demonstrates the main measures and construction achievements of the major construction practice in Southeast University from multiple aspects. These aspects include optimizing the professional training program and the professional curriculum system, promoting the transformation of scientific research achievements into teaching resources, emphasizing the cultivation of practical links in engineering and innovative abilities, and strengthening the structure of the teaching staff. It highlights the characteristics of the coordinated development of " knowledge-ability-literacy-mission" and the cultivation of undergraduate talents with "high-quality, high-capable and high-innovative " in our university. Furthermore, within the new context of "New Engineering Education and New Infrastructure Construction", it explores approaches to fully harmonize the relationship and the distribution of class hours between traditional civil engineering courses (such as geology, mechanics and structure) and emerging courses like artificial intelligence, informatization and big data. The practical exploration and research achievements of our university’s major construction can provide guidance, set examples, and play a leading role for the development of undergraduate programs in Urban Underground Space Engineering nationwide.