To improve the quality of talents training of road, bridge and river-crossing engineering, based on analyzing the influencing factors on the quality of graduation design of road, bridge and river-crossing engineering in depth, some quality control measures of the graduation design of this major were proposed aiming at the current situation of graduation design of this major. The quality control measures relate to the time arrangement, topic selection, and process management, subjective cognizance of the undergraduate and the team construction of the academic advisors.