Smoke ventilation is an important part of industrial ventilation, but also indispensable to HVAC design, due to the lack of practical engineering experience, students for this part of the learning difficulties, to solve the contradiction between theory with practice, improve the effectiveness and pertinence of teaching content, this paper adopted in different stages of teaching with different teaching methods, that is, from the introduction of the early stage of the numerical simulation technology, the application of case teaching is to the middle, late to the implementation of the collaborative project teaching, practice has proved that these teaching methods can effectively arouse the enthusiasm of students’autonomous learning, make students become the main body of the learning process. The students reflect well, get the expected teaching effect.