At present, college acts as the main body of the civil engineering professional education, and the content of professional courses emphasis on theoretical knowledge. This mechanism is no longer suitable for the current employment environment and industry trends. The college should take the initiative to explore new educational mechanism to adapt to the social and economic development. We pointed out the positive significance of college-enterprise cooperation education mechanism, and discussed measures of practicing the mechanism, which included the enterprise participating in developing the training plan, the college and the enterprise establishing practice bases together, technical staff participating in course teaching, and personnel exchange between the college and the enterprise. The practice result shows that the measures are effective, which are beneficial attempts of educational mechanism innovation.