Integrating information technology and teaching, incorporating online and offline blended course construction and application into the system engineering of improving teaching quality and personnel training level, is the focus of current teaching research and practice. Taking blended learning and flipped classroom instructional mode as the theoretical framework, this study presented a flipped classroom teaching mode based on self-developed SPOC (small private online course) and applied it to a university-based scientific translation course. Online teaching resources design, online and offline mixed teaching process design and assessment design were devised and practiced. It showed that the SPOC-based flipped classroom blender teaching can enhance students' interest in learning and lead to better collaborative learning as well. It provides reference for colleges and universities to build online and offline blended courses and to carry out SPOC-based flip classroom teaching.