This paper discusses how to strengthen regional economic cooperation, realize accelerated development and exert direct jurisdiction and central city function of Chongqing on the conditions of international and domestic economic integration After reviewing the regional economic cooperation status and existing problems of Chongqing, we put forward “113” countermeasures which include emphasizing one focus—the upper reaches of the Yangtze River economic zone, resolving one difficulty—regional economic cooperation and coordination difficulty and taking three specific measures—accelerates self-development, uses state policy support efficiently, and improves the coordination mechanism For perfecting of the regional cooperation mechanisms, we advise to establish a regional cooperation and coordination mechanism whose main part is non-governmental organizations—the fourth party platform, and pay equal attention to the Government and non-governmental forces, which bases on polycentric governance theory