Comprehensive reform is the new strategy startup point of regional economy development of China, and also one of pivots to promoting region harmony and balanced developmentThe core of national comprehensive reform is possessed of special power of antecedence and foretaste which corresponds with a omni directional system variance and innovation course The antecedence and foretaste reform of social and economy fields may bring some correlative problem and conflict, cause instability of the testing district and disturb synthetically reform process successfully The aim of this study on risk assessment and alert mechanism of comprehensive reform experimental zones is to put forward reasonable advice on risk answer and risk precaution of experimental zones