Facing the fierce global competition, enterprises, staff with professional knowledge is the enterprise’s the sources core competitiveness. Increasing employees job satisfaction has a positive role to enterprise. Hackman and Oldham thought that the improvement of work can stirr up the incentive to every worker to a higher job satisfaction in 1975, but there are also researchers found that even the same work done by different workers, because of the difference of the personality traits of individual workers, will lead to different degree of satisfaction.Therefore, based on the topfive personality traits (Big Five) framework, this study proposes that individual personality differences will interfere the relationship between job charader and job satisfaction.After multiple regression analysis, the study finds that: (1) Education variables can significantly predict job satisfaction.The job satisfaction of graduate and postgraduate student workers is higher that of the college student workers and below. (2) The more the worker understand teh potential of incentives of the work, the higher the job satisfaction. (3) The higher the exoraversion personality of workers, the higher the job satisfaction. (4) The sense of responsibility would positively interfere with the relationship between the potencial incentives of the job and job satisfaction. The higher the scores of the potential incentives of the job, the higher the job satisfaction will come across to the workers with higher sense of responsibility.