Research on scientific issues belongs to the frontier of science philosophy.Many scientists and philosophers regard the issue as a power source and theoretical development of science, but the traditional philosophy of science places less emphasis on the research of scientific problems itself. This does not mean that traditional philosophy avoids discussion of"problem".On the contrary, in the theoretical discussion, some famous science philosophers' discussion of the issues is often involved.Dewey, Poper, Laudan, Kuhn, Lakatos and other famous philosophers disscussed the "problem" in their works, some domestic scholars of "problem" theory has been studied and formed some distinctive ideas.It is important to sort out and review their theories about "problem"and prospect the future of the theoretical research on the "problem" for new development of science and philosophy, and promote research of "problem school".