Bonded zones (BZs) and export processing zones (EPZs) are the core carriers of reform and opening-up policy,and play an important role in guiding and promoting the processing trade development. Based on the provincial panel data from 2004 to 2015,this paper analyzes the impact and interaction of the BZs and EPZs on the processing trade development. It is found that BZs and EPZs promote the processing trade development,and the substitution effects are significant. The regional differences in the promotion effects on processing trade development and interaction of BZs and EPZs are significant. Further analysis finds that the regional differences in the promotion effects on different trade type processing trade development and interaction of BZs and EPZs are significant.