The development of the digital economy has played an important role in promoting the innovation-driven strategy of the Yangtze River Economic Belt,in achieving high-quality economic development,and in addressing the problem of inadequate development imbalance. Based on the digital economic index,by using spatial econometric model and mathematical statistics analysis,this paper attempts to explore the spatial pattern of the digital economy in the Yangtze River Economic Belt and its influencing factors. The results show that the development level of the digital economy in the Yangtze River Economic Belt is generally low,the geographical distribution is significantly different,and the development level is decreasing from the downstream to the upstream. The digital economic city hierarchy is not dominated by the economic level and does not completely follow the existing geospatial-based hierarchy. The digital economy of the Yangtze River Economic Belt is a hotspot-transitional-secondary hotspot-cold-point spatial differentiation pattern,and cities such as Shanghai,Suzhou,and Jiaxing are digital economic hotspots; geographically weighted regression results show that information level of development,city level,and industrial structure have significantly improved the level of digital economic development in the Yangtze River Economic Belt. The economic level,population size,and human capital have little effect,which means that regions with poor economic bases can also rely on upgrading information infrastructure and promoting industrial upgrading,and develop the digital economy to achieve economic "changing the road and overtaking". Accordingly,it is proposed to set up institutions to formulate policies to promote the growth of the digital economy,create a base,cultivate a brand,and enhance the digital economy,deepen cooperation,and innovate digital economic models.