Based on the panel data of each province, this paper analyzes the influence of resource dependence on China's regional economic growth, and discusses its influence mechanism and transmission path by using the panel smooth transformation regression model. In the univariate model, the transmission mechanism that plays a relatively important role in resources and economic growth is the level of opening up. The multi-factor panel smoothing transformation model is more optimized than the single-factor model, and the explanation of economic phenomena is more reasonable. The results show that:resource dependence can cause "curse" to economic growth, and its effect varies with the level of technology input, human capital, industrial structure, manufacturing investment and the degree of opening up in different provinces; under other constant conditions, the big output value of the second industry that is formed by means of the resource dependence has certain restriction effect on economic growth; the difference of the open degree is a typical middle transmission mechanism, which impacts the resource dependence and the economic growth. The backward and forward linkages of resources should be strengthened to avoid the "resource curse".