Enterprise development is inseparable from innovative R&D activities, and driving enterprise innovation enthusiasm requires joint efforts at three levels: macro, meso and micro. Existing studies have explored the impact on innovation intention from the perspective of micro corporate social responsibility, but there is a lack of in-depth exploration of the corresponding path. To this end, this article takes the state-owned listed companies of Shanghai and Shenzhen A shares from 2013 to 2018 as a sample, chooses to introduce intermediate variables of government subsidies, studies the path of corporate social responsibility on innovation intention, and discusses the moderating effect of mixed ownership reform degree path from the macro level. It is found that: 1)Corporate social responsibility positively affects corporate’s innovation intention; 2)Government subsidies play an intermediary role between corporate social responsibility and innovation intention; 3)Mixed ownership reform can positively regulate the relationship between social responsibility and innovation intention. Through further analysis, the article also concludes: The mediating role of government subsidies in corporate social responsibility and innovation intention in the current period is more significant, and the degree of mixed ownership has a more obvious regulatory role in corporate social responsibility and innovation intention in the previous period. The research results provide theoretical support and empirical basis for SOEs to effectively drive innovation intention and deepen the reform of mixed ownership through fulfilling their social responsibilities.