The great anti-epidemic spirit is an important part of the CPC's spiritual pedigree. Examining the great anti-epidemic spirit from the perspective of spiritual pedigree will not only help deepen the research of the CPC's spiritual pedigree, but also help expand the understanding of the great anti-epidemic spirit. "How to form" the great anti-epidemic spirit is as important as and deeper than "what it is" and "how to carry it forward". The exploration of "how to form" is helpful to clarify the essence of the great anti-epidemic spirit and improve the pertinence of inheritance and promotion. The great anti-epidemic spirit is the lofty spiritual realm embodied by the Chinese people leading by the CPC in the desperate struggle against the COVID-19 epidemic. It inherits the red gene of the CPC's spiritual pedigree and also has its own rich connotation and characteristic. The CPC and the people are the creators of great anti-epidemic spirit. The CPC is the leading body of the anti-epidemic struggle, the leading group of the Party is the initiator of the fundamental task and the controller of the fundamental direction of the anti-epidemic struggle, the leading cadres of the Party at all levels are the designers and leading executors of the specific strategies of the anti-epidemic struggle in various fields, and the ordinary Party members are the active participants and backbone forces of all anti-epidemic fronts. The Chinese people are the basic subjects of the anti-epidemic struggle, their anti-epidemic appeal is the fundamental driving force for the anti-epidemic struggle, their anti-epidemic wisdom is the basic element of the anti-epidemic struggle, and their anti-epidemic actions are the direct support of the anti-epidemic struggle. Marxism is the theoretical basis for the Party to lead the people in the anti-epidemic struggle, and it is also the ideological weapon to fight and confront with all kinds of wrong statements at home and abroad. The material basis and institutional advantages of socialism with Chinese characteristics are the source of confidence of the Party in leading the people to fight the epidemic, and also the purpose that the Party and the people unite to fight the epidemic. The firm belief of the Party and the people in Marxism and socialism with Chinese characteristics is the logical basis for the formation of the great anti-epidemic spirit. The Party and the people cast a great anti-epidemic spirit with actions. Under the leadership of the Party, the Chinese people concretize their feelings for the motherland and compatriots into the monumental anti-epidemic action. The anti-epidemic practice of strict self-discipline of the Chinese people, the anti-epidemic practice of watching and helping each other, and the anti-epidemic practice of risking one's life to forget one's death together constitute the practical basis for the formation of the great anti-epidemic spirit. Chinese culture deeply nourishes the Party and the people. The Party and the people draw wisdom from Chinese excellent traditional culture, the ideological essence of overcoming difficulties from revolutionary culture, and the strength of fighting epidemic from advanced socialist culture. Chinese culture is the cultural foundation for the formation of great anti-epidemic spirit. A profound understanding of the formation of the great anti-epidemic spirit and strengthening the spiritual support for overcoming epidemic are of great significance to win the overall victory of the anti-epidemic struggle and the great struggle in the new era.